Winclove Clear 



A new probiotic formulation aimed at the prevention of recurrent urinary tract infections

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Urinary tract infections


A urinary tract infection (UTI) is a bacterial infection of the urinary tract and occurs at least once in a lifetime among one third of women [1,2]. A recurrent UTI (rUTI) is defined as two episodes of UTI in six months or three or more in one year. Between 35% to 53% of women treated for UTIs will experience an rUTI within twelve months[3].

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Figure 1:

Risk factors for urinary tract infections


Studies have shown that the urinary tract is inhabited by micro-organisms and has its own unique microbial community. While it is still unknown what causes a UTI, some factors thought to disturb the urinary tract are changes in hygiene, medication, sexual activity and diet (see figure 1). The treatment standard for UTIs are antibiotics. Although antibiotics are very effective initially, they don’t work the same way for every patient and are not ideal for long term use, as happens in preventative use for rUTIs. Also, there is no  consensus on the ideal dose, duration, and schedule within UTIs[4]. Antibiotics cannot  support the host and therefore don’t help to resolve the risk of longterm infection recurrence[5]. Finally, antibiotics come with many negative side effects such as antibiotic resistance. These side effects have prompted researchers to look into alternatives such as probiotics to support treatment and to prevent rUTIs.

Winclove Clear is a multispecies probiotic formulation that inhibits pathogen growth in the vagina and bladder, and stimulates the immune system in the gut


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Inhibition of the uropathogen E. coli by the probiotic strains in Winclove Clear. The higher the inhibition zone, the better the inhibition.

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Effect on the epithelial barrier function by the strains in Winclove Clear. An increase in % TEER indicates an improved barrier function

Formulation characteristics


Winclove Clear is developed to inhibit growth of pathogens in the vagina and bladder, and stimulate the immune system. This is achieved by combining probiotics with the functional ingredient cranberry. Cranberry is well-known for its capacities as a non-antibiotic treatment in case of a rUTI.

The probiotic strains in Winclove Clear have been tested and selected in vitro for their capacity to:

• survive the gastro-intestinal tract

• inhibit pathogens
• adhere to surface of epithelial cells
• form aggregations
• positively stimulate the immune system
(decrease production of IL-6 and IL-8 and
increase production of IL-10)
• strengthen the gut barrier function
• produce lactic acid.

The capacity of the probiotic strains to inhibit the uropathogen E.coli is shown in the figure. E.coli often enters the bladder via the vagina from the rectum and is able to colonize the bladder epithelium. The graph shows that all strains in Winclove Clear are very well capable of inhibiting E.coli.

The effect of the probiotic strains to strengthen the gut epithelial barrier is shown in the second figure. For this, trans epithelial electric resistance (TEER) was measured in a transwell system of a CaCo2 cell line. An increase in the percentage of TEER indicates an improved barrier function. The graph shows that all strains in Winclove Clear are capable to strengthen the barrier function.

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1 Salvatore S, Salvatore S, et al. Urinary tract infections in women. Eur J Obstet Gynecol Reprod Biol. 2011;156(2):131-136.
2 Warren JW, Abrutyn E, et al. Guidelines for antimicrobial treatment of uncomplicated actue bacteril cystitis and acute pyelonephritis in women. Infectious Diseases Society of America (IDSA). Clin Infect Dis.  999;29(4):745-758.
3 Ikäheimo R, Siitonen A, et al. Recurrence of urinary tract infection in primary care setting: analysis of a 1-year followup of 179 women. Clin Infect Dis. 1996;22:91-99.
4 Alberts X, Huertas I, et al. Antibiotics for preventing recurrent urinary tract infection in non-pregnant women.
Rev Urol. 2004;3:11-17.
5 Reid G, Bruce AW. Urogenital infections in women: can probiotics help? Postgrad Med J. 2003;79:428-432.






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