Lactobacillus plantarum WCFS1


Lactobacillus plantarum WCFS1, identical to Winclove's L. plantarum W1, is a highly investigated bacterial strain. Its complete genome has been sequenced in 2003. Due to the presence of this genome sequence and genetic tools, L. plantarum WCSF1 has been extensively studied. Now researchers have reviewed this work, with a focus on host interaction. 










Lactobacillus plantarum WCFS1 shows a high survival capacity in the human gastrointestinal tract, and different molecular mechanisms of how this bacteria responds to stress (like acid or oxygen) have been identified. Also multiple genes of this bacterium involved in the interaction with other microorganisms have been found and investigated. For interaction with the host, extracellular proteins are important and interaction of these proteins with the host epithelial barrier and the immune system have also been studied in detail.








"Lactobacillus plantarum W(CFS)1 is the second most studied bacterial strain in the world".






Ecologic CLEAR_400

Figure 1,   The amount of performed studies for several probiotic strains.




Although a lot of molecular work has been done with L. plantarum  WCSF1, limited work from human studies is available. However, the molecular work indicate potential of this strain as probiotic, such as effects on epithelial barrier function, stimulation of Th1 cells, and the potential to remove cholesterol.


Hence the authors  advocate the use of L. plantarum WCFS1 and other isolates of L. plantarum NCIMB8826 in human trials as to capitalize on the wealth of knowledge.


Read the scientific article on Microbial Biotechnology 










Lactobacillus plantarum WCFS1

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