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New meta-analysis:

Probiotics during pregnancy can reduce allergy and eczema in infants

One of the largest ever conducted studies about the impact of maternal diet on the development of allergy and eczema in children demonstrates that probiotic supplementation during the last weeks of pregnancy and lactation can reduce eczema by 22%, a noteworthy number [1].

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The development of the microbiota already starts in utero and continues to evolve the first years of life. During our lifetime the microbiota co-develops with our immune system. Establishing a healthy intestinal microbiota in early life contributes to proper intestinal development and maturation of the immune system. There is evidence that the early diet influences the development of immune-mediated health conditions such as allergy and auto-immune diseases [2].

Recent guidelines from the World Allergy Organization already recommend probiotic and prebiotic supplements for eczema prevention [3,4]. Though, European, North American and Australian guidelines do not yet support these recommendations. However, recent focused systematic reviews support a relationship between probiotics and prebiotics and reduced eczema risk [3,5,6]





The researchers investigated over 400 intervention studies that evaluated the relationship between diet during pregnancy, lactation, or the first years of life, and future risk of allergic or autoimmune disease. Evidence from 19 intervention trials evaluating the effect of probiotic supplements on risk of allergic diseases were included. In their analyses, the PANDA trial with Winclove’s probiotic formulation Ecologic PANDA, was also included .

The researchers found a robust association between probiotic supplementation and reduced eczema (Risk ratio 0.78) in children before the at age of 4. This means a risk reduction of 22%, or 44 cases per 1000 children.

In 22% of newborn babies the risk of developing eczema could be reduced if the mother takes a probiotic supplement during the last weeks of her pregnancy and the first  months of life

This comprehensive review has made clear that a mother’s diet during pregnancy and lactation may influence the risk that her child develops an allergic disease. The authors conlude: 

"A daily probiotic supplement taken from around 36 to 38 weeks gestation through the first to 6 months of lactation, may reduce risk of eczema in the child."

Furthermore, they make strong recommendation to guidelines committees to carefully consider these key findings and revise their guidelines..





Read the scientific article 


1.       Garcia-Larsen et al. Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis. PLoS Med. 2018 Feb 28;15(2):e1002507

2.       Prescott SL. Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases. J Allergy Clin Immunol. 2013; 131(1): 23–30

3.       Cuello-Garcia CA et al. World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Prebiotics. World Allergy Organ J. 2016; 9: 10

4.       Fiocchi A, et al. World Allergy OrganizationMcMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics. World Allergy Organ J. 2015; 8(1): 4

5.       Cuello-Garcia CA, et al. Probiotics for the prevention of allergy: A systematic review and meta-analysis of randomized controlled trials. J Allergy Clin Immunol. 2015; 136(4): 952–961.

6.       Osborn DA, Sinn JK. Prebiotics in infants for prevention of allergy. Cochrane Database Syst Rev. 2013; 3: CD006474.










probiotics aid in eczema

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