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Study results show;

Ecologic® PANDA benefits both mother and child 

The probiotic formulation Ecologic® PANDA  has shown to prevent early-onset of eczema in new born babies [1]. Moreover, a German study indicates that Ecologic® PANDA  can also reduce GI-health complaints of the mother during pregnancy [2]. In this new study, women taking  Ecologic® PANDA experienced less flatulence and constipation compared to data known from literature. In addition, the infants experienced less symptoms of colic. This new data allows a broader positioning of Ecologic® PANDA, in which both mother and child can benefit.  

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GI-complaints & Pregnancy

For most women, pregnancy is one of the most wonderful phases in life. However, these 9 months also have their though moments in which the other “joys” of pregnancy manifest. Hormonal, immunological, and metabolic changes can contribute to various physical and emotional discomforts. Constipation and flatulence are  common gastro-intestinal (GI) complaints and affect about 50% of the women at some point during pregnancy [3]. In non-pregnant women, probiotics have demonstrated to reduce GI-complaints with very few side effects [4]. Probiotics have also shown to decrease colic symptoms in infants [5,6]. This led to a German gynaecologist hypothesizing  whether probiotics could do the same for pregnant women.

The study

In this new study, Prim. Univ.-Doz. Dr. Hannes Hofmann from the Department of Gynaecology and Obstetrics at the State Hospital of Feldbach-Furstenfeld investigated whether probiotics could reduce constipation and flatulence during pregnancy and infant colic after birth. 148 pregnant women and their babies were given 3 grams of Ecologic® PANDA (in Germany marketed by Insititute Allergosan) from the last 2 months of pregnancy until the babies were 4 months old.  During this period, the women filled out a daily questionnaire to record GI-symptoms and crying behaviour of their baby. The data showed that pregnant women taking Ecologic® PANDA experienced less constipation and flatulence compared to reference data known from literature.  Additionally, the babies experienced less colicky symptoms. 


 5.3 % of the women experienced flatulence (reference data from literature 40%)

 2,4 % of the women experienced constipation  (reference data from literature 40%)

 4.9 % of the babies were colicky (reference data from literature 3-28%).

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The b2b probiotic formulation Ecologic PANDA is not comercially available and not intended for consumers to cure or prevent any diseases.

Ecologic®  PANDA

The multispecies probiotic formulation Ecologic® PANDA  is specifically developed to prevent eczema in babies. It can modulate the intestinal microbiota in such a way that the immune system reacts to allergens with a relatively mild response [7]. Previous clinical research has shown that perinatal administration of Ecologic® PANDA significantly reduced eczema in babies at 3 months, an effect that is sustained until the age of two (the PANDA trial) [1,8].

The Word Allergy Organization (WAO) also recommends probiotics to pregnant women and children at high risk  for allergies [9].

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What does this study mean for you?

This current study shows that Ecologic® PANDA can relieve expectant mothers from constipation and flatulence and decreased colic symptoms in their newborn babies.  We know that marketing a probiotic for the prevention of a disorder (like eczema) that might occur later in life can be very challenging in today’s fast-paced world  where consumers are looking for instant effects. However, this study shows that Ecologic® PANDA can also be advised to relieve existing discomfort and hence allows a much broader positioning of the formulation. 

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Educational  Support  

We are happy to support you in how to communicate these results to your healthcare professionals and how to implement them into your educational materials. For this, please contact Karen Koning, Senior Scientist and Head of Education at Winclove Probiotics. 

Read the scientific study




1.     Niers L.E. et al. (2009) The effects of selected probiotic strains  on the development of eczema (the PandA study), 64(9):1349-1358.

2.     Hoffman, H. (2015) Probiotikum gegen Verdauungsbescwerden in der Schwangerschaft. Gynäkologie & Geburtshilfe.

3.     Bradley, C. S., Kennedy, C. M., Turcea, A. M., Rao, S. S., & Nygaard, I. E. (2007). Constipation in pregnancy: prevalence, symptoms, and risk factors. Obstetrics & Gynecology, 110(6), 1351-1357.

4.     Koebnick, C., Wagner, I., Leitzmann, P., Stern, U., & Zunft, H. J. (2003). Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Canadian Journal of Gastroenterology and Hepatology, 17(11), 655-659.

5.     Savino, F., Cordisco, L., Tarasco, V., Palumeri, E., Calabrese, R., Oggero, R., & Matteuzzi, D. (2010). Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics, 126(3), e526-e533.

6.     Savino, F., Pelle, E., Palumeri, E., Oggero, R., & Miniero, R. (2007). Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics, 119(1), e124-e130.

7.     Niers, L. E., Hoekstra, M. O., Timmerman, H. M., Van Uden, N. O., De Graaf, P., Smits, H. H., & Rijkers, G. T. (2007). Selection of probiotic bacteria for prevention of allergic diseases: immunomodulation of neonatal dendritic cells. Clinical & Experimental Immunology, 149(2), 344-352.

8.     Gorissen, D. M., Rutten, N. B. M. M., Oostermeijer, C. M., Niers, L., Hoekstra, M. O., Rijkers, G. T., & Van der Ent, C. K. (2014). Preventive effects of selected probiotic strains on the development of asthma and allergic rhinitis in childhood. The Panda study. Clin Exp Allergy, 44(11), 1431-3.

9.     Fiocchi A. et al. World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics. WAO journal. 2015;8(1):4.








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