The microbiota and gut barrier in MC
An increased permeability of the epithelial barrier is associated with many gastrointestinal disorders, including MC. Inflammation influences the intestinal permeability and is widely linked to MC. Multiple studies have also indicated the presence of pro-inflammatory cytokines and other immune response factors in MC patients. It therefore comes as no surprise that an increased intestinal permeability is observed in MC patients.
Probiotics for microbiota management
A possible way to interact with the microbiota is by intake of probiotics. Many beneficial effects that might influence MC management have already been found. These include:
Protective effect on the epithelial barrier function in pouchitis patients
Reduced stool frequency and
improved consistency in collagenous colitis patients
Short-term clinical response and improvement of MC symptoms