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Fatigue

-an indication area for probiotics?

The relation between gut problems and fatigue has been noted for years but the exact underlying mechanisms are not completely clear yet. Research is now pointing towards an involvement of the gut-brain axis. Recent studies have demonstrated the ability of probiotics to influence gut-brain communication and brain-functioning.  Winclove is now setting up research to further explore the possibility of probiotics to influence symptoms of fatigue.

 

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Fatigue, characterized by general exhaustion, extreme tiredness, weakness or lack of energy, is a common and poorly understood symptom affecting 8% of the general population[1]. Prior studies have demonstrated that up to 44% of patients with Irritable Bowel Disease (IBD) in clinical remission experience significant fatigue symptoms [2]. Symptoms of fatigue are more significant in patients with Crohn’s Disease than in patients with Ulcerative Colitis but not related to disease activity[3].

 

A previous prospective cohort study has shown that significant fatigue symptoms were associated with complex immune dysregulation in IBD patients in remission [4]. Those patients with significant fatigue also reported higher depression and anxiety, as was also found in other previous studies [5]. This led the researchers hypothesize that fatigue could be more related to potential gut-brain mechanisms than to disease-activity.

 

The Crohn’s and Colitis Centre of the Massachussets General Hospital (MGH) will in collaboration with Winclove perform an exploratory RCT to improve our understanding of fatigue and the role of the microbiome and probiotics.

 

The quiescent IBD population offers a fitting ‘model’ to this research since there is high incidence of fatigue, even when there is no disease activity. The primary outcomes measures are designed to evaluate the effect of the probiotic supplement on fatigue symptoms,  composition of stool microbiome, serum inflammatory cytokines level, metabolomics profiles, in quiescent IBD patients. 100 patients will be randomly assigned to the probiotic (Ecologic Barrier) or placebo group and will use the probiotic twice daily (total daily CFU 4x10^10) for 12 weeks.

 

Winclove is excited about this new collaboration and we will keep you updated on the study proceedings and outcomes.

 

 

 

 

 

References

1.Schwarz, R., O. Krauss, and A. Hinz, Fatigue in the general population. Onkologie, 2003. 26(2): p. 140-4.

2. Bager, P., et al., Fatigue in out-patients with inflammatory bowel disease is common and multifactorial. Aliment Pharmacol Ther, 2012. 35(1): p. 133-41.

3.Grimstad, T., et al., Fatigue in Newly Diagnosed Inflammatory Bowel Disease. J Crohns Colitis, 2015. 9(9): p. 725-30.

4. Borren, N.Z., et al., Fatigue in quiscent inflammatory bowel disease is associated with low GM-CSF levels and metabolomic alterations. Presented at the digestive disease week, Chicago, IL, USA. May 2017.            

5.Norton, C., et al., Assessing fatigue in inflammatory bowel disease: comparison of three fatigue scales. Aliment Pharmacol Ther, 2015. 42(2): p. 203-11.

 

 

 

Fatigue, an indication area for probiotics?

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